ML221

Product Specifications

CAS Number

877636-42-5

Target

Arrestin|||Apelin receptor

Related Pathways

GPCR/G Protein

Purity

0.9774

Bioactivity

ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 ?M in the cAMP assay, and 1.75 ?M in the ?-arrestin assay, and EC80 of 10 nM in both assays.

Smiles

[O-][N+](=O)c1ccc(cc1)C(=O)Oc1coc(CSc2ncccn2)cc1=O

Molecular Formula

C17H11N3O6S

Molecular Weight

385.35

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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