EN460

EN460 is a selective endoplasmic reticulum oxidation 1 (ERO1) inhibitor. EN460 (IC50 of 1.9 μM) interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation[1].

Product Specifications

CAS Number

[496807-64-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endoplasmic Reticulum Oxidoreductase 1 (ERO1)

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/EN460.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC(F)(F)C1=NN(C2=CC(C(O)=O)=C(Cl)C=C2)C(/C1=C\C3=CC=C(C4=CC=CC=C4)O3)=O

Molecular Formula

C22H12ClF3N2O4

Molecular Weight

460.79

Precautions

H302, H315, H319, H335

References & Citations

[1]Blais JD, et al. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem. 2010 Jul 2;285 (27) :20993-1003.