SB334867 HCl
Product Specifications
CAS Number
249889-64-3
Target
OX Receptor
Related Pathways
Neuroscience, GPCR/G Protein
Bioactivity
SB-334867 (SB 334867A) is a potent, selective, and blood-brain barrier permeable antagonist of the orexin-1 (OX1) receptor, demonstrating significant selectivity against OX2 (pKb=7.4), and exhibiting 100-fold selectivity over 5-HT2B and 5-HT2C, with pKi values of 5.4 and 5.3, respectively [1]. This compound effectively reduces ethanol consumption and obstructs the development of morphine-induced sensitization to locomotor activity in vivo [2] [3].
Smiles
Cl.Cc1nc2ccc(NC(=O)Nc3ccnc4cccnc34)cc2o1
Molecular Formula
C17H14ClN5O2
Molecular Weight
355.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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