Aftin-4

Aftin-4, an amyloid forty-two inducer, activates ?-secretase, promoting the generation of amyloid-?-1-42 (A?1-42) from amyloid-? protein precursor. Aftin-4 (Aftin4) increased A?-1-42, but not A?-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 (Aftin4) can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.