Aftin-4
Product Specifications
CAS Number
866893-90-5
Target
Gamma-secretase|||Beta Amyloid
Related Pathways
Neuroscience|||Stem Cells|||Proteases/Proteasome
Purity
0.9903
Bioactivity
Aftin-4, an amyloid forty-two inducer, activates ?-secretase, promoting the generation of amyloid-?-1-42 (A?1-42) from amyloid-? protein precursor. Aftin-4 (Aftin4) increased A?-1-42, but not A?-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 (Aftin4) can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.
Smiles
CC[C@H](CO)Nc1nc(N(C)Cc2ccccc2)c2ncn(C(C)C)c2n1
Molecular Formula
C20H28N6O
Molecular Weight
368.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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