What is the catalog number for CBL0137 hydrochloride?

The catalog number for CBL0137 hydrochloride is T4361.

What sizes are available for CBL0137 hydrochloride?

CBL0137 hydrochloride is available in the following size(s): 1 mg, 1 mL - 10 mM (in DMSO), 5 mg, 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does CBL0137 hydrochloride come in?

CBL0137 hydrochloride is available in 7 different pack sizes.

Is CBL0137 hydrochloride in stock?

CBL0137 hydrochloride is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CBL0137 hydrochloride?

CBL0137 hydrochloride is manufactured by Molfinity.

What is the estimated delivery time for CBL0137 hydrochloride?

Estimated delivery time for CBL0137 hydrochloride is approximately 10 business day(s), depending on your location.

CBL0137 hydrochloride

Product Specifications

CAS Number

1197397-89-9

Target

P53, NF-κB, MDM-2/p53

Related Pathways

Apoptosis, NF-κB

Purity

0.9986

Bioactivity

CBL0137 hydrochloride (Curaxin-137 hydrochloride) is an inhibitor of the histone chaperone FACT, which also activates p53 and inhibits NF-κB with EC50 values of 0.37 and 0.47 μM, respectively. CBL0137 hydrochloride functionally inactivates the complex that promotes chromatin transcription (FACT), thereby driving effects on p53 and NF-κB and promoting cancer cell death, and when used in combination with cisplatin, CBL0137 hydrochloride has potent anticancer activity against SCLC.