CBL0137 hydrochloride
Product Specifications
CAS Number
1197397-89-9
Target
P53, NF-κB, MDM-2/p53
Related Pathways
Apoptosis, NF-κB
Purity
0.9986
Bioactivity
CBL0137 hydrochloride (Curaxin-137 hydrochloride) is an inhibitor of the histone chaperone FACT, which also activates p53 and inhibits NF-κB with EC50 values of 0.37 and 0.47 μM, respectively. CBL0137 hydrochloride functionally inactivates the complex that promotes chromatin transcription (FACT), thereby driving effects on p53 and NF-κB and promoting cancer cell death, and when used in combination with cisplatin, CBL0137 hydrochloride has potent anticancer activity against SCLC.
Smiles
Cl.CC(C)NCCn1c2ccc(cc2c2cc(ccc12)C(C)=O)C(C)=O
Molecular Formula
C21H25ClN2O2
Molecular Weight
372.88
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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