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Betrixaban

Product Specifications

CAS Number

330942-05-7

Target

Factor Xa

Related Pathways

Metabolism

Purity

0.9935

Bioactivity

Betrixaban (PRT054021) is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity [3]. Betrixaban, now developed by Portola Pharmaceuticals Inc., is prescribed as a venous thromboembolism (VTE) prophylactic for adult patients with moderate to severe restricted motility or with other risks for VTE [2]. VTE can be manifested as deep vein thrombosis or pulmonary embolism and it is a leading cause of preventable death in hospitalized patients [4].

Smiles

COc1ccc(NC(=O)c2ccc(cc2)C(=N)N(C)C)c(c1)C(=O)Nc1ccc(Cl)cn1

Molecular Formula

C23H22ClN5O3

Molecular Weight

451.91

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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