Prexasertib mesylate
Product Specifications
CAS Number
1234015-55-4
Target
Chk, Apoptosis, Others, DNA/RNA Synthesis
Related Pathways
Others, Apoptosis, DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
Prexasertib is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia. LY2606368 causes replication catastrophe and antitumor effects through CHK1-dependent mechanisms. Treatment of cells with LY2606368 results in the rapid appearance of TUNEL and pH2AX-positive double-stranded DNA breaks in the S-phase cell population.
Smiles
N#CC1=NC=C(N=C1)NC2=NNC(=C2)C=3C(OC)=CC=CC3OCCCN.O=S(=O)(O)C
Molecular Formula
C19H23N7O5S
Molecular Weight
461.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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