I-CBP112 hydrochloride
Product Specifications
CAS Number
2147701-33-3
Target
Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Purity
0.9969
Bioactivity
I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly reduced the leukemia-initiating potential of MLL-AF9 (+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. Interestingly, I-CBP112 increased the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin.
Smiles
O(C[C@@H]1CN(C)CCC1)C2=C3C(=CC(=C2)C4=CC(OC)=C(OC)C=C4)CN(C(CC)=O)CCO3.Cl
Molecular Formula
C27H37ClN2O5
Molecular Weight
505.05
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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