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PF-3758309 hydrochloride

Product Specifications

CAS Number

1279034-84-2

Target

Apoptosis, PAK

Related Pathways

Cytoskeletal Signaling, Apoptosis

Purity

>99.99%

Bioactivity

PF-3758309 hydrochloride (PF-03758309 hydrochloride), is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hydrochloride binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.

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Cl.CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(C)nc4ccsc34)n[nH]c2C1(C)C)c1ccccc1

Molecular Formula

C25H31ClN8OS

Molecular Weight

527.08

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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