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E6446

Product Specifications

CAS Number

1219925-73-1

Target

TLR, Stearoyl-CoA Desaturase (SCD)

Related Pathways

Immunology/Inflammation, Metabolism

Purity

0.9999

Bioactivity

E6446 inhibits Toll-like receptor (TLR) 7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When administered to mice, this compound suppress responses to challenge doses of cytidine-phosphate-guanidine (CpG) -containing DNA, which stimulates TLR9.

Smiles

O(CCCN1CCCC1)C=2C=C3C(N=C(O3)C4=CC=C(OCCCN5CCCC5)C=C4)=CC2

Molecular Formula

C27H35N3O3

Molecular Weight

449.59

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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