TS-24

TS-24 is an inhibitor for cathepsin S, with an IC50 of 4.3 μM. TS-24 exhibits radiosensitizing activity in wild type breast cancer susceptibility gene 1 (BRCA1) and in TNBC xenograft mice model, through induction of apoptosis[1].

Product Specifications

CAS Number

[1563260-97-8]

UNSPSC

12352005

Target

Apoptosis; Cathepsin

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ts-24.html

Concentration

10mM

Purity

98.96

Solubility

DMSO : ≥ 16.67 mg/mL

Smiles

O=C(/C=C/C1=CN(C)C2=C1C=CC=C2)C3=CC4=CC=CC=C4O3

Molecular Formula

C20H15NO2

Molecular Weight

301.34

References & Citations

[1]Choi E, et al., Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple-negative breast cancer cells. Cancer Sci. 2024 Apr 13.