TS-24
TS-24 is an inhibitor for cathepsin S, with an IC50 of 4.3 μM. TS-24 exhibits radiosensitizing activity in wild type breast cancer susceptibility gene 1 (BRCA1) and in TNBC xenograft mice model, through induction of apoptosis[1].
Product Specifications
CAS Number
1563260-97-8
UNSPSC
12352005
Target
Apoptosis; Cathepsin
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ts-24.html
Concentration
10mM
Purity
98.96
Solubility
DMSO : ≥ 16.67 mg/mL
Smiles
O=C(/C=C/C1=CN(C)C2=C1C=CC=C2)C3=CC4=CC=CC=C4O3
Molecular Formula
C20H15NO2
Molecular Weight
301.34
References & Citations
[1]Choi E, et al., Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple-negative breast cancer cells. Cancer Sci. 2024 Apr 13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin S
Available Sizes
Frequently Asked Questions
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