Lometrexol hydrate
Product Specifications
CAS Number
1435784-14-7
Target
Apoptosis, Caspase, Bcl-2 Family, Others, Antifolate
Related Pathways
Proteases/Proteasome, Others, Apoptosis, Cell Cycle/Checkpoint
Bioactivity
Lometrexol hydrate (DDATHF hydrate) is an antipurine antifolate compound that inhibits glycinamide ribonucleotide formyltransferase (GARFT) activity without inducing detectable DNA strand breaks. It further disrupts de novo purine synthesis, leading to abnormal cell proliferation, apoptosis, and cell cycle arrest, exhibiting anticancer activity [1] [2]. Additionally, it acts as a potent inhibitor of human Serine hydroxymethyltransferase1/2 (h SHMT1/2) [3].
Smiles
O.Nc1nc2NC[C@H](CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Cc2c(=O)[nH]1
Molecular Formula
C21H27N5O7
Molecular Weight
461.475
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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