CBL0137
Product Specifications
CAS Number
1197996-80-7
Target
P53, MDM-2/p53, NF-κB, Histone Acetyltransferase
Related Pathways
Chromatin/Epigenetic, NF-κB, Apoptosis
Purity
0.9968
Bioactivity
CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM) . It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preClinicalal models of pancreatic cancer.
Smiles
C(CNC(C)C)N1C=2C(C=3C1=CC=C(C(C)=O)C3)=CC(C(C)=O)=CC2
Molecular Formula
C21H24N2O2
Molecular Weight
336.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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