Verrucarin A
Product Specifications
CAS Number
456069
Target
Others|||ROS|||Apoptosis|||Reactive Oxygen Species
Related Pathways
Metabolism|||Apoptosis|||Immunology/Inflammation|||NF-?B|||Others
Bioactivity
Verrucarin A (Muconomycin A) is a Type D macrocyclic mycotoxin. Verrucarin A (VA), derived from the pathogen fungus Myrothecium verrucaria, is a protein synthesis inhibitor that inhibits the growth of leukemia cell lines and activates caspases, apoptosis, and inflammatory signaling in macrophages. It effectively increases the phosphorylation of p38 MAPK and diminishes the phosphorylation of ERK/Akt. Additionally, Verrucarin A causes cell cycle deregulation through the induction of p21 and p53 [1] [2].
Smiles
CC12[C@@]3([C@@]4(O[C@]5([C@]1(COC(=O)[C@@H](O)[C@H](C)CCOC(=O)\C=C\C=C\C(=O)O[C@@]2(C4)[H])CCC(C)=C5)[H])[H])CO3
Molecular Formula
C27H34O9
Molecular Weight
502.55
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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