GSK 2833503A
Product Specifications
CAS Number
1366234-01-6
Target
Others, TRP/TRPV Channel
Related Pathways
Membrane transporter/Ion channel, Others
Bioactivity
GSK 2833503A is a potent and selective TRPC6 and TRPC3 antagonist (IC50 = 3-16 nM and 21-100 nM, respectively) . GSK 2833503A exhibits >63-fold selectivity over other ion channels, including other TRP channels, CaV1.2, hERG and NaV1.5. GSK 2833503A suppresses angiotensin II or endothelin-1-induced cardiac hypertrophy signaling in HEK293 cellsin vitroand in cardiomyocytes.
Smiles
C(=O)(C=1N=C(NC2=C(F)C=C(Cl)C=C2)SC1C)N3[C@@H](C)[C@@H](C)CCC3
Molecular Formula
C18H21ClFN3OS
Molecular Weight
381.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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