CG 428
Product Specifications
CAS Number
2412055-93-5
Target
Trk receptor, PROTACs
Related Pathways
PROTAC, Tyrosine Kinase/Adaptors
Purity
0.9986
Bioactivity
CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM. CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 joined by a linker to the cereblon E3 ligase ligand pomalidomide. CG 428 shows selectivity for TRKA over TRKC and TRKB with Kds of 1nM, 4.2 nM, and 28 nM. CG 428 inhibits the growth of KM12 colon cancer cells with an IC50 of 2.9 nM.
Smiles
O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCC(=O)N4CCN(CC4)C=5N=C(C=CC5)C=6N7C(=NC6)C=CC(=N7)N8[C@H](CCC8)C9=CC(F)=CC=C9
Molecular Formula
C43H43FN10O6
Molecular Weight
814.86
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
CSB-DT4617 1 g
6-Amino-4-cyanopyridine- 3-boronic acid pinacol ester
Sign In for Pricing
View Details A04085-3-Fluoro647 100 µg/Vial
Anti-Aspartate Aminotransferase/GOT1 Antibody Picoband® Fluoro647 Conjugated
Sign In for Pricing
View Details 
R2031-38M-FITC 200 µL
RPS6KB1, phosphorylated (Ser418) (Ribosomal Protein S6 Kinase beta-1, S6K-beta-1, S6K1, 70kD Ribosomal Protein S6 Kinase 1, P70S6K1, p70-S6K 1, p70 Ribosomal S6 Kinase alpha, p70 S6 Kinase alpha, p70 S6K-alpha, p70 S6KA, p70-S6K, Ribosomal Protein S6 Kinase I, Serine/threonine-protein Kinase 14A, STK14A) (FITC) discontinued
Sign In for Pricing
View Details