CG 428
Product Specifications
CAS Number
2412055-93-5
Target
Trk receptor, PROTACs
Related Pathways
PROTAC, Tyrosine Kinase/Adaptors
Purity
0.9986
Bioactivity
CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM. CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 joined by a linker to the cereblon E3 ligase ligand pomalidomide. CG 428 shows selectivity for TRKA over TRKC and TRKB with Kds of 1nM, 4.2 nM, and 28 nM. CG 428 inhibits the growth of KM12 colon cancer cells with an IC50 of 2.9 nM.
Smiles
O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCC(=O)N4CCN(CC4)C=5N=C(C=CC5)C=6N7C(=NC6)C=CC(=N7)N8[C@H](CCC8)C9=CC(F)=CC=C9
Molecular Formula
C43H43FN10O6
Molecular Weight
814.86
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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