FTI 277 TFA
Product Specifications
CAS Number
1217447-06-7
Target
Others|||Apoptosis|||Ras|||Transferase
Related Pathways
MAPK|||Apoptosis|||Metabolism|||Others
Bioactivity
FTI 277 TFA is a prodrug form of FTI 276 that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM) . Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10?M respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
Smiles
OC(=O)C(F)(F)F.COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1
Molecular Formula
C24H30F3N3O5S2
Molecular Weight
561.64
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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