BRD PHOTAC-I-3
Product Specifications
CAS Number
2370997-94-5
Target
Others
Related Pathways
Others
Bioactivity
BRD PHOTAC-I-3 is a photoswitchable BET bromodomain degrader (PHOTAC, PHOtochemically TArgeting Chimera) . BRD PHOTAC-I-3 comprises a ligand for an E3 ligase, a photoswitch, and the BET bromodomain targeting ligand (+) -JQ1. Exhibits cytotoxicity and degrades BRD4, BRD3 and to a lesser extent BRD2 in lymphoblast cells upon irradiation with 390 nm light, but not in the dark.
Smiles
COc1cc(cc(OC)c1OCC(=O)NCCCCNC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1)\N=N\c1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O |c:25|
Molecular Formula
C46H47ClN10O8S
Molecular Weight
935.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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