AY 254
Product Specifications
CAS Number
2093408-03-6
Target
Protease-activated Receptor
Related Pathways
GPCR/G Protein
Bioactivity
AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release) . Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cellsin vitro.
Smiles
C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C1CCCCC1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |@@:25|
Molecular Formula
C30H49N9O6
Molecular Weight
631.779
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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