FC 11
Product Specifications
CAS Number
2271035-37-9
Target
PROTACs, FAK
Related Pathways
Cytoskeletal Signaling, Angiogenesis, Tyrosine Kinase/Adaptors, PROTAC
Bioactivity
FC 11 is a highly potent focal adhesion Ki nase (FAK) PROTAC®Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide. The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.
Smiles
O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCN4C=C(C(NC5=CC=C(NC=6N=C(NCC7=C(N(S(C)(=O)=O)C)N=CC=C7)C(C(F)(F)F)=CN6)C=C5)=O)N=N4
Molecular Formula
C41H42F3N13O9S
Molecular Weight
949.91
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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