MS 154N
Product Specifications
CAS Number
2675490-97-6
Target
Others, PROTACs, EGFR
Related Pathways
PROTAC, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Others, Angiogenesis
Bioactivity
MS 154N is a negative control for MS 154. The compound exhibits high binding-affinity for WT and L858R-mutant EGFR (Kdvalues are 3 and 4.3 nM, respectively), but does not significantly induce degradation of EGFR mutants.
Smiles
O=C1C=2C(C(=O)N1C3C(=O)N(C)C(=O)CC3)=CC=CC2OCCCCCCCCNC(CCN4CCN(CCCOC5=CC6=C(C=C5OC)N=CN=C6NC7=CC(Cl)=C(F)C=C7)CC4)=O
Molecular Formula
C47H56ClFN8O8
Molecular Weight
915.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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