Phototrexate
Product Specifications
CAS Number
2268033-83-4
Target
DHFR, Others
Related Pathways
Others, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Metabolism
Bioactivity
Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR) . Phototrexate is a photochromic analog of Methotrexate. Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) light; it can be switched off (trans-Phototrexate) by blue or white light and by thermal relaxation in the dark.cis-Phototrexate (IC50 = 6 nM) significantly reduces the viability of HeLa cells compared withtrans-Phototrexate (IC50 = 34 μM) .
Smiles
NC=1C2=C(C=CC(/N=N/C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=C2)N=C(N)N1
Molecular Formula
C20H19N7O5
Molecular Weight
437.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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