What is the catalog number for P53R3?

The catalog number for P53R3 is T41068.

What sizes are available for P53R3?

P53R3 is available in the following size(s): 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg.

How many pack sizes does P53R3 come in?

P53R3 is available in 7 different pack sizes.

P53R3 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures P53R3?

P53R3 is manufactured by Molfinity.

What is the estimated delivery time for P53R3?

Estimated delivery time for P53R3 is approximately 10 business day(s), depending on your location.

P53R3

Product Specifications

CAS Number

922150-12-7

Target

MDM-2/p53, p53

Related Pathways

Apoptosis

Purity

0.988

Bioactivity

P53R3 is a potent reactivator of p53, effectively restoring sequence-specific DNA binding to several p53 hot spot mutants, namely p53 R175H, p53 R248W, and p53 R273H. This compound exhibits p53-dependent antiproliferative effects with significantly higher specificity compared to PRIMA-1 and promotes the recruitment of both wild-type p53 and p53 M237I to various target gene promoters. Additionally, P53R3 markedly increases the mRNA, total protein, and cell surface expression of death receptor 5 (DR5), demonstrating its utility in cancer research.