PA-8
Product Specifications
CAS Number
878437-15-1
Target
PACAP
Related Pathways
GPCR/G Protein
Purity
0.9764
Bioactivity
PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vpac2 receptors. PA-8 also inhibited PacAP-induced elevation of cAMP levels in vitro (IC50 = 2 nM) and PacAP-induced aversive response and mechanical atopic pain after intrathecal injection in vivo.
Smiles
COc1cc(ccc1OCC=C)C1CC(=O)Nc2nc(N)[nH]c(=O)c12
Molecular Formula
C17H18N4O4
Molecular Weight
342.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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