AG126
Product Specifications
CAS Number
118409-62-4
Target
COX|||ERK
Related Pathways
Immunology/Inflammation|||MAPK|||Neuroscience
Purity
0.9872
Bioactivity
AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 ?M. It blocks the production of TNF-? in vitro2 and in vivo, attenuating signaling through NF-?B, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 ?M) and platelet-derived GFRK (IC50 > 100 ?M) .
Smiles
Oc1cc(C=C(C#N)C#N)ccc1[N+]([O-])=O
Molecular Formula
C10H5N3O3
Molecular Weight
215.16
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/78DB9EFF-E523-4221-8698-144F6A2550F5/T4092
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1052033-01 0.02 mg (E-Coli)
Recombinant Bacillus thuringiensis subsp. kurstaki Putative RNA polymerase sigma-G factor
Ask
View Details MBS1052033-02 0.1 mg (E-Coli)
Recombinant Bacillus thuringiensis subsp. kurstaki Putative RNA polymerase sigma-G factor
Ask
View Details 
MBS1052033-03 0.02 mg (Yeast)
Recombinant Bacillus thuringiensis subsp. kurstaki Putative RNA polymerase sigma-G factor
Ask
View Details 
MBS1052033-04 0.1 mg (Yeast)
Recombinant Bacillus thuringiensis subsp. kurstaki Putative RNA polymerase sigma-G factor
Ask
View Details 
MBS1052033-05 0.02 mg (Baculovirus)
Recombinant Bacillus thuringiensis subsp. kurstaki Putative RNA polymerase sigma-G factor
Ask
View Details MBS1052033-06 0.02 mg (Mammalian-Cell)
Recombinant Bacillus thuringiensis subsp. kurstaki Putative RNA polymerase sigma-G factor
Ask
View Details