AG126
Product Specifications
CAS Number
118409-62-4
Target
COX|||ERK
Related Pathways
Immunology/Inflammation|||MAPK|||Neuroscience
Purity
0.9872
Bioactivity
AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 ?M. It blocks the production of TNF-? in vitro2 and in vivo, attenuating signaling through NF-?B, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 ?M) and platelet-derived GFRK (IC50 > 100 ?M) .
Smiles
Oc1cc(C=C(C#N)C#N)ccc1[N+]([O-])=O
Molecular Formula
C10H5N3O3
Molecular Weight
215.16
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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