TPBM
TPBM is a potent estrogen receptor α (ERα) inhibitor with an IC50 value of 9 μM for 17β-estradiol (E2) -ERα. TPBM reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TPBM inhibits E2-dependent growth of ERα-positive cancer cells (IC50=5 μM) . TPBM is not toxic to cells and does not affect estrogen-independent cell growth[1].
Product Specifications
CAS Number
6466-43-9
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tpbm.html
Purity
98.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1C)N(C)C2=C(N=C(CSCC3=CC=CC=C3)N2)C1=O
Molecular Formula
C15H16N4O2S
Molecular Weight
316.38
References & Citations
[1]Mao C, et al. A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells. J Biol Chem. 2008;283 (19) :12819-12830.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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