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TPBM

TPBM is a potent estrogen receptor α (ERα) inhibitor with an IC50 value of 9 μM for 17β-estradiol (E2) -ERα. TPBM reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TPBM inhibits E2-dependent growth of ERα-positive cancer cells (IC50=5 μM) . TPBM is not toxic to cells and does not affect estrogen-independent cell growth[1].

Product Specifications

CAS Number

6466-43-9

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tpbm.html

Purity

98.51

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1C)N(C)C2=C(N=C(CSCC3=CC=CC=C3)N2)C1=O

Molecular Formula

C15H16N4O2S

Molecular Weight

316.38

References & Citations

[1]Mao C, et al. A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells. J Biol Chem. 2008;283 (19) :12819-12830.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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