Repotrectinib
Product Specifications
CAS Number
1802220-02-5
Target
ROS, ALK, ROS Kinase, Trk receptor, Src
Related Pathways
Immunology/Inflammation, Tyrosine Kinase/Adaptors, Angiogenesis
Purity
>99.99%
Bioactivity
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 values of 1.01 nM for WT ALK, 5.3 nM for SRC, 1.08 nM for ALK L1196M, and 1.26 nM for ALK G1202R.
Smiles
C[C@H]1CNC(=O)c2cnn3ccc(N[C@H](C)c4cc(F)ccc4O1)nc23
Molecular Formula
C18H18FN5O2
Molecular Weight
355.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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