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Avatrombopag hydrochloride

Product Specifications

CAS Number

570403-17-7

Target

Others|||Thrombopoietin Receptor

Related Pathways

Immunology/Inflammation|||Others

Bioactivity

Avatrombopag hydrochloride (AKR-501) is an orally active, nonpeptide agonist of the thrombopoietin (TPO) receptor with an EC50 of 3.3 nM. It effectively mimics TPO by stimulating platelet production through activation of the intracellular signaling system, facilitating platelet and megakaryocyte generation from hemopoietic precursor cells. Additionally, Avatrombopag hydrochloride serves as a substrate for cytochrome P450 [CYP] 2C9 and CYP3A.

Smiles

Cl.OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(-c2cc(Cl)cs2)c(s1)N1CCN(CC1)C1CCCCC1

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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