Avatrombopag hydrochloride
Product Specifications
CAS Number
570403-17-7
Target
Others|||Thrombopoietin Receptor
Related Pathways
Immunology/Inflammation|||Others
Bioactivity
Avatrombopag hydrochloride (AKR-501) is an orally active, nonpeptide agonist of the thrombopoietin (TPO) receptor with an EC50 of 3.3 nM. It effectively mimics TPO by stimulating platelet production through activation of the intracellular signaling system, facilitating platelet and megakaryocyte generation from hemopoietic precursor cells. Additionally, Avatrombopag hydrochloride serves as a substrate for cytochrome P450 [CYP] 2C9 and CYP3A.
Smiles
Cl.OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(-c2cc(Cl)cs2)c(s1)N1CCN(CC1)C1CCCCC1
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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