CAY10602
Product Specifications
CAS Number
374922-43-7
Target
Sirtuin
Related Pathways
DNA Damage/DNA Repair|||Chromatin/Epigenetic
Purity
>99.99%
Bioactivity
CAY10602 is a SIRT1 activator derived from high throughput screening for compounds that enhance SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays indicate that CAY10602 dose-dependently suppresses NF-?B-dependent induction of TNF-? by lipopolysaccharide in THP-1 cells, achieving approximately 75% inhibition at 60 ?M without cytotoxicity.
Smiles
Nc1c(c2nc3ccccc3nc2n1-c1ccc(F)cc1)S(=O)(=O)c1ccccc1
Molecular Formula
C22H15FN4O2S
Molecular Weight
418.44
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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