Lesogaberan napadisylate
Product Specifications
CAS Number
477956-38-0
Target
Others|||GABA Receptor
Related Pathways
Neuroscience|||Others|||Membrane transporter/Ion channel
Bioactivity
Lesogaberan (AZD-3355) napadisylate is a potent and selective agonist of GABA B receptors, with an EC50 of 8.6 nM for human recombinant GABA B receptors. It has an affinity (Ki) of 5.1 nM for rat GABA B receptors and 1.4 ?M for GABA A receptors, determined by displacement of [3H]GABA binding in brain membranes. Lesogaberan napadisylate exerts a peripheral mode of action, inhibiting transient lower esophageal sphincter relaxation.
Smiles
NC[C@H](F)CP(O)=O.OS(=O)(=O)c1ccc2ccccc2c1
Molecular Formula
C13H17FNO5PS
Molecular Weight
349.31
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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