NH-3
Product Specifications
CAS Number
447415-26-1
Target
Thyroid hormone receptor (THR)
Related Pathways
Endocrinology/Hormones
Purity
0.994
Bioactivity
NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.
Smiles
CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)cc(C#Cc2ccc(cc2)[N+]([O-])=O)c1O
Molecular Formula
C28H27NO6
Molecular Weight
473.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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