AST 487
Product Specifications
CAS Number
630124-46-8
Target
FLT, VEGFR, c-RET, c-Kit, Bcr-Abl
Related Pathways
Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, Apoptosis, Angiogenesis
Purity
0.9956
Bioactivity
AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.
Smiles
C(C1=C(C(F)(F)F)C=C(NC(NC2=CC=C(OC=3C=C(NC)N=CN3)C=C2)=O)C=C1)N4CCN(CC)CC4
Molecular Formula
C26H30F3N7O2
Molecular Weight
529.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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