AST 487

630124-46-8

FLT, VEGFR, c-RET, c-Kit, Bcr-Abl

Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, Apoptosis, Angiogenesis

0.9956

AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.

C(C1=C(C(F)(F)F)C=C(NC(NC2=CC=C(OC=3C=C(NC)N=CN3)C=C2)=O)C=C1)N4CCN(CC)CC4

C26H30F3N7O2

529.56

Ice Packs

-20°C