AST 487

Product Specifications

CAS Number

630124-46-8

Target

FLT|||VEGFR|||c-RET|||c-Kit|||Bcr-Abl

Related Pathways

Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling|||Apoptosis|||Angiogenesis

Purity

0.9956

Bioactivity

AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.

Smiles

C(C1=C(C(F)(F)F)C=C(NC(NC2=CC=C(OC=3C=C(NC)N=CN3)C=C2)=O)C=C1)N4CCN(CC)CC4

Molecular Formula

C26H30F3N7O2

Molecular Weight

529.56

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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