8-Aminoadenosine
Product Specifications
CAS Number
3868-33-5
Target
DNA/RNA Synthesis|||Others|||Akt|||Apoptosis|||Autophagy|||mTOR
Related Pathways
DNA Damage/DNA Repair|||PI3K/Akt/mTOR signaling|||Others|||Autophagy|||Apoptosis|||Cell Cycle/Checkpoint|||Cytoskeletal Signaling
Bioactivity
8-Aminoadenosine (8-NH2-Ado) is an RNA-directed nucleoside analogue that effectively diminishes cellular ATP levels and impedes mRNA synthesis. It also obstructs Akt/mTOR signaling, inducing autophagy and apoptosis in a p53-independent manner. Its significant antitumor activity underscores its therapeutic potential.
Smiles
NC=1N(C=2C(N1)=C(N)N=CN2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
Molecular Formula
C10H14N6O4
Molecular Weight
282.26
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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