DUTP (trisodium)

DUTP trisodium (2´-Deoxyuridine, 5´-Triphosphate) is the salt form of dUTP. dUTP is a metabolic intermediate in both procaryotes and eucaryotes. dUTP can be used in PCR and RT-PCR to replace dTTP, resulting in the uracil-containing PCR products suitable for most standard applications. dUTP is found to inhibit the enzyme - Cytidine Aminohydrolase from sheep liver[1][2][3][4].

Product Specifications

CAS Number

[102814-08-4]

Product Name Alternative

2'-Deoxyuridine-5'-triphosphate (trisodium salt)

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H335, H360

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dutp-trisodium.html

Purity

99.74

Solubility

DMSO : < 1 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 125 mg/mL (ultrasonic)

Smiles

O=P(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])OC[C@@H]1[C@@H](O)C[C@H](N2C(NC(C=C2)=O)=O)O1

Molecular Formula

C9H12N2Na3O14P3

Molecular Weight

534.09

Precautions

H315, H317, H319, H335, H360

References & Citations

[1]Nayun Kim, et al. dUTP incorporation into genomic DNA is linked to transcription in yeast. Nature. 2009 Jun 25;459 (7250) :1150-3.|[2]Grafstrom, R. H., et al., (1978) . The incorporation of uracil into animal cell DNA in vitro. Cell, 15 (1), 131–140.