T-2513
Product Specifications
CAS Number
288247-87-0
Target
Others|||DNA/RNA Synthesis|||Topoisomerase
Related Pathways
DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Others
Bioactivity
T-2513 is a potent and specific inhibitor of topoisomerase I. It acts by forming covalent bonds with the topoisomerase I-DNA complex, thereby enhancing its stability. This interaction disrupts the normal process of DNA replication and RNA synthesis, ultimately resulting in cellular apoptosis.
Smiles
CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OCCCN)cc12
Molecular Formula
C25H27N3O5
Molecular Weight
449.507
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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