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T-2513

Product Specifications

CAS Number

288247-87-0

Target

Others|||DNA/RNA Synthesis|||Topoisomerase

Related Pathways

DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Others

Bioactivity

T-2513 is a potent and specific inhibitor of topoisomerase I. It acts by forming covalent bonds with the topoisomerase I-DNA complex, thereby enhancing its stability. This interaction disrupts the normal process of DNA replication and RNA synthesis, ultimately resulting in cellular apoptosis.

Smiles

CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OCCCN)cc12

Molecular Formula

C25H27N3O5

Molecular Weight

449.507

Shipping Conditions

Cool pack

Storage Temperature

-20°C

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