PARP/EZH2-IN-1
Product Specifications
CAS Number
2687273-52-3
Target
Others, Histone Methyltransferase, PARP
Related Pathways
Others, DNA Damage/DNA Repair, Chromatin/Epigenetic
Bioactivity
PARP/EZH2-IN-1 is a novel dual inhibitor targeting PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM), showing promising potential for treating triple-negative breast cancer with wild-type BRCA.
Smiles
CC(=O)Nc1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCN(CC1)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F
Molecular Formula
C43H41FN8O5
Molecular Weight
768.85
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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