CDK12-IN-4
Product Specifications
CAS Number
2651196-69-7
Target
Others, CDK
Related Pathways
Cell Cycle/Checkpoint, Others
Bioactivity
CDK12-IN-4, a pyrazolotriazine compound, exhibits potent inhibition of CDK12 by achieving an IC50 value of 0.641 μM, utilizing high ATP levels (2 mM) . Notably, CDK12-IN-4 does not impact CDK2/Cyclin E (IC50 > 20 μM) or CDK9/Cyclin T1 (IC50 > 20 μM) under the influence of high ATP (2 mM) levels (WO2021116178A1) .
Smiles
Fc1ccc2nc(CNc3nc(nc4c(cnn34)C3CC3)N3CCOCC3)[nH]c2c1F
Molecular Formula
C20H20F2N8O
Molecular Weight
426.432
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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