SR-0813
Product Specifications
CAS Number
2597186-19-9
Target
Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Purity
0.9972
Bioactivity
SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9, with an IC50 of 25 nM and EC50 of 205 nM for the ENL YEATS domain, and an IC50 of 311 nM and EC50 of 76 nM (CETSA) for the AF9 YEATS domain. It shows over 100-fold lower affinity for MAP3K19 (Kd = 3.5 μM) compared to ENL YEATS (Kd = 30 nM) . SR-0813 can be utilized in acute leukemia research.
Smiles
C(NC1CCC1)(=O)C2=CN3C(=NC(=C3)C4=CC(NS(NCCN5CCCCC5)(=O)=O)=CC=C4)C=C2
Molecular Formula
C25H32N6O3S
Molecular Weight
496.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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