MRTX849 ethoxypropanoic acid
Product Specifications
CAS Number
2561529-98-2
Target
Target Protein Ligand-Linker Conjugate|||Others|||Kras|||Ras
Related Pathways
MAPK|||PROTAC|||GPCR/G Protein|||Others
Bioactivity
MRTX849 ethoxypropanoic acid is a compound that contains a ligand for KRAS G12C and a PROTAC linker. It is commonly employed in the synthesis of PROTAC LC-2, which is a highly effective and innovative PROTAC. LC-2 has been proven to degrade endogenous KRAS G12C with remarkable potency, exhibiting DC50 values ranging from 0.25 to 0.76 ?M.
Smiles
OC(=O)CCOCCCN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C(F)=C)c1cccc2cccc(Cl)c12
Molecular Formula
C37H43ClFN7O5
Molecular Weight
720.24
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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