SGC2085 HCl
Product Specifications
CAS Number
1821908-49-9
Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Purity
0.9991
Bioactivity
SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulator of Wnt/β-catenin transcription and neoplastic transformation in colorectal cancer as well as a critical factor in estrogen-stimulated breast cancer growth, and its depletion results in decreased proliferation of myeloid leukemia cells in vivo.
Smiles
C(=O)([C@H](C)N)NCc1cc(c(cc1)Oc1cc(cc(c1)C)C)C.Cl
Molecular Formula
C19H24N2O2·HCl
Molecular Weight
348.87
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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